Discover CalyFX




If you like CBD, you will LOVE CBG!
CBG is the precursor to all other cannabinoids. It will not make you high and has the most incredible health benefits. Cannabigerol (CBG) is more powerful when taken sublingually (under the tongue). CBG is processed by the body’s natural Endocannabinoid system. This system is made up of molecules and receptors that are responsible for keeping our bodies in an optimal state by interacting with the brain’s CB1 and CB2 receptors. CBG reacts similarly to our Endocannabinoid system which behaves as a modulator for our immune system, nervous system, and nearly all our body’s organs.
CBG is rich in antioxidants and boasts antibacterial and antifungal properties. Experience first hand the amazing benefits of CBG to truly understand and FEEL THE EFFECTS.


The fundamental difference is how they work within the human body. CBD helps regulate the body’s own Endocannabinoid system (ECS) whilst CBG interacts with the brains’ CB1 and CB2 receptors.
What does the Endocannabinoid System do and why does it need to be regulated? The Endocannabinoid system is the primary homeostatic regulatory system of the body, this means it maintains, and stabilises all aspects of the body from the Nervous System, metabolism stress and mood, to immune health and inflammatory response. CBD helps regulate the Endocannabinoid system and prevents the endocannabinoids from being broken down, thus allowing them to be the most effective.
CBG however, interacts slightly differently. CBG binds directly to both our CB1 and CB2 receptors efficiently delivering its benefits directly into our various systems within our body. What do our CB1 and CB2 receptors do? CB1 receptors are present in organs such as the spleen, in white blood cells, the nervous system and the brain. CB2 receptors are again found in the nervous system and play an essential role in pain management, discomfort and immune function. CBG helps stimulate and strengthen both of these receptors.


The name CalyFx is a portmanteau, blending the words: Calyx (from the female flower), California (where our products are made), and Fx (for the effects our customers enjoy from our custom strains).
CalyFx founder, Dennis D’Alessio, has a special interest in the medical potential of Hemp extracted treatments. He had a younger brother, Bill, who was Autistic and suffered from Epilepsy. The only legal treatment available to abate Bill’s symptoms were expensive, with severe side effects, which took a toll on his other vital organs and reduced his quality of life. Eventually, Bill’s kidneys stopped functioning and he was placed on dialysis. Ultimately, a grand-mal seizure led to Bill’s death at the age of 32.
CalyFx’s full and broad-spectrum hemp extracted products contain CBD, CBG, CBN, and some 1300+ other elements and are naturally derived substances from the hemp and plant that have been used by humans for thousands of years.
Dennis and his team created CalyFx to challenge the worlds’ leading PhDs, Researchers, and experts to create life enhancing products. Today, CalyFx has created a custom line of hemp based formulations to help provide assistance for certain markets around the world. Our all-natural strains are available in vapes, tinctures, topicals, sprays, and water. CalyFx also offers custom formulations and white label services. All CalyFx strains are 100% natural and made in the USA to the highest standards. Our strains are always third party tested and packaged in lead-free and heavy metal-free containers and devices.


Since the beginning, Humans have used Hemp plants to heal themselves from all kinds of ailments. As it turns out, different strains do different things and help in different ways. Now, after decades of research from Doctors and health professionals from around the world, CalyFx has designed custom strains for certain effects. CalyFx has developed 8 custom strains: Focus, Chill, Sleep, Shape, Sex, Relief, Social, and Endurance. CalyFx only uses FDA registered and 100% pure hemp extract that is always CO2 extracted in ISO certified labs. It is only blended with 100% plant-based terpenes and other natural nutrients to create the world’s best super strains. CalyFx has discovered that when certain combinations of terpenes, in precise amounts, along with other natural plant elements are added to full spectrum Hemp oil, true magic happens.
CalyFx does not make any Health claims. CalyFx is in compliance with the MHRA (U.K.) and FDA (U.S.) legislation not allowing any manufacturer of Hemp or oil to make Health claims. If anyone purchases any of our effect strains and does not experience the effect of the product, they will always get a full refund.

CALYFX does not sell or distribute any products that are in violation of the United States Controlled Substances Act.
The company does sell and distribute products that contain hemp-derived ingredients.

The information and products contained on this website have not been evaluated by the FDA and are not intended to diagnose, treat, or cure any disease.

You are advised to consult with your health care practitioner prior to use. Please visit our full Terms of Use page for more information on the terms and conditions governing your use of this website.